4 found shot dead around UK car in French Alps

PARIS (AP) ? Four people were found shot to death on a forest road in the French Alps on Wednesday, their bodies left in and near a car with British license plates, authorities said. A girl discovered at the site with bullet wounds was hospitalized.

Police combed the wooded hills around the village of Chevaline into the night in search of possible perpetrators. Forensic experts were heading to the site where a startled cyclist came across the corpses during a leisure ride.

Two of the victims were women, two men, police said. But their identities and nationalities are unclear. The British Foreign Office said it was aware of reports of the incident and was looking into it.

The girl was in critical condition Wednesday night in a nearby hospital, said an official with the gendarme service for the Haute-Savoie region. The official was not authorized to be publicly named. The gendarme service ? a kind of police force ? had initially said that she died.

A cyclist on the rugged road discovered the bodies and the girl in the afternoon and alerted emergency authorities, Prosecutor Eric Maillaud said.

Three bodies were found in a BMW sports utility vehicle registered in Britain ? a male driver and two women in the back seat, Maillaud said. The body of a male cyclist was found nearby, and the wounded girl was found near the vehicle. A large number of bullet casings were scattered around the car.

About 60 officers fanned out in the forest to search for possible perpetrators, a gendarme captain at the site said on French television.

Police blocked off the road where the bodies were found. A sign at the mouth of the route reads "Dangerous Road" in French, English and German, in reference to its rough terrain.

Autopsies are planned for Thursday or Friday, the prosecutor said.

The bodies were found in an area in the foothills of the Alps known for its springs and waterfalls, not far from Lake Annecy.

___

Cassandra Vinograd in London contributed to this report.

Source: http://news.yahoo.com/4-found-shot-dead-around-uk-car-french-190043037.html

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Lana Del Ray Shows Off Her New Locks In London

The I'm Not Obsessed Media family includes ImNotObsessed.com, BabyRazzi.com, and LadyandtheBlog.com. I'm Not Obsessed offers work-safe and family-friendly insight into the vast array of the latest celebrity gossip, paparazzi photos, and up-to-the minute pop culture news. INO is never nasty, snarky, rude, or perverse. BabyRazzi offers work-safe and family-friendly insight into the latest celebrity gossip, paparazzi photos, and up-to-the minute pop culture news with a targeted focus on celebrity babies, pregnancies, and all things family and relationships. In addition, BabyRazzi offers product reviews. Lady and the Blog focuses on fashion, family and food. It offers beauty and fashion reviews, shopping trends, designer previews, and full runway coverage. Lady and the Blog provides our readers with the latest in family news, product reviews, steals and deals and features great buys from online retailers. I'm Not Obsessed, Inc. publishes rumors and conjecture in addition to accurately reported facts. Information on this site may or may not be true and I'm Not Obsessed, Inc. makes no warranty as to the validity of any claims. LEGAL DISCLAIMER AND IMNOTOBSESSED.COM TERMS OF USE.

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Scientists design molecule that reverses some fragile X syndrome defects

ScienceDaily (Sep. 4, 2012) ? Scientists on the Florida campus of The Scripps Research Institute have designed a compound that shows promise as a potential therapy for one of the diseases closely linked to fragile X syndrome, a genetic condition that causes mental retardation, infertility, and memory impairment, and is the only known single-gene cause of autism.

The study, published online ahead of print in the journal ACS Chemical Biology September 4, 2012, focuses on tremor ataxia syndrome, which usually affects men over the age of 50 and results in Parkinson's like-symptoms -- trembling, balance problems, muscle rigidity, as well as some neurological difficulties, including short-term memory loss and severe mood swings.

With fragile X syndrome, tremor ataxia syndrome, and related diseases, the root of the problem is a structural motif known as an "expanded triplet repeat" -- in which a series of three nucleotides are repeated more times than normal in the genetic code of affected individuals. This defect, located in the fragile X mental retardation 1 (FMR1) gene, causes serious problems with the processing of RNA.

"While there is an abundance of potential RNA drug targets in disease, no one has any idea how to identify or design small molecules to target these RNAs," said Mathew Disney, a Scripps Research associate professor who led the study. "We have designed a compound capable of targeting the right RNA and reversing the defects that cause fragile X-associated tremor ataxia."

Preventing Havoc

In tremor ataxia syndrome, the expanded triplet repeat leads to the expression of aberrant proteins that wreak widespread havoc. The repeats actually force the normal proteins that regulate RNA splicing -- necessary for production of the right kind of proteins -- into hiding.

The compound designed by Disney and his colleagues not only improves the RNA splicing process, but also minimizes the ability of repeats to wreak havoc on a cell.

"It stops the repeat-associated defects in cell culture," Disney said, "and at fairly high concentrations, it completely reverses the defects. More importantly, the compound is non-toxic to the cells. It looks like a very good candidate for development, but we're still in the early stages of testing."

Overall, this study reinforces Disney's earlier findings showing it is possible to identify and develop small molecules that target these traditionally recalcitrant RNA defects. In March of this year, Disney published a study in the Journal of the American Chemical Society that described a small molecule that inhibited defects in myotonic dystrophy type 1 RNA in both cellular and animal models of disease.

"We've gotten very good at targeting RNA with small molecules, something a lot of people said couldn't be done," Disney pointed out. "Our approach is evolving into a general method that can be used to target any disease that is associated with an RNA, including, perhaps, fragile X syndrome itself."

The new compound also works as a probe to better understand how these repeats cause fragile X syndrome and how they contribute to tremor ataxia, Disney added.

In addition to Disney, authors of the study, "Small Molecule That Targets r(CGG) and Improves Defects in 2 Fragile X?Associated Tremor Ataxia Syndrome," include Biao Liu, Wang-Yong Yang, Tuan Tran, and Jessica L. Childs-Disney of Scripps Research; and Nicolas Charlet-Berguerand and Chantal Sellier of the Institut de G?n?tique et de Biologie Mol?culaire et Cellulaire (IGBMC), Institut National de la Sant? et de la Recherche M?dicale (INSERM), the Centre National de la Recherche Scientifique (CNRS), and University of Strasbourg, Illkirch, France.

The study was funded by the National Institutes of Health (award numbers 3R01GM079235-02S1 and 1R01GM079235-01A2), INSERM, the French National Research Agency, and The Scripps Research Institute.

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The above story is reprinted from materials provided by Scripps Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal References:

1. Matthew D. Disney, Biao Liu, Wang-Yong Yang, Chantal Sellier, Tuan Tran, Nicolas Charlet-Berguerand, Jessica L. Childs-Disney. A Small Molecule That Targets r(CGG)expand Improves Defects in Fragile X-Associated Tremor Ataxia Syndrome. ACS Chemical Biology, 2012; 120904130429000 DOI: 10.1021/cb300135h
2. Raman Parkesh, Jessica L. Childs-Disney, Masayuki Nakamori, Amit Kumar, Eric Wang, Thomas Wang, Jason Hoskins, Tuan Tran, David Housman, Charles A. Thornton, Matthew D. Disney. Design of a Bioactive Small Molecule That Targets the Myotonic Dystrophy Type 1 RNA via an RNA Motif?Ligand Database and Chemical Similarity Searching. Journal of the American Chemical Society, 2012; 134 (10): 4731 DOI: 10.1021/ja210088v

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/DHYDVTmOrmc/120904170924.htm

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America

What happens when the racist elders of America takes over? Segregation comes back hard. Now all of America is re-segregated, and the elders are trying to turn our generation racist and make things how they used to be.

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Quest for Higgs boson enters new phase

ScienceDaily (Sep. 4, 2012) ? In The Hitchhiker's Guide to the Galaxy, the humorous answer to the Ultimate Question of Life, the Universe, and Everything turned out to be an ambiguous "42."

This summer, University of Chicago particle physicists and their colleagues at the Large Hadron Collider in Geneva announced the discovery of what may be the closest thing to a scientific counterpart of The Hitchhiker's Guide's whimsical figure. Their experiments revealed a new particle with a mass somewhere between 125 and 126 giga-electron volts, or 134 times the mass of the proton. This figure falls within the predicted range for the Higgs boson, which acquired a decidedly unscientific nickname -- "The God Particle" -- after the title of a book co-written by Nobel laureate Leon Lederman, the Frank E. Sulzberger Professor Emeritus in Physics.

Physicists at UChicago and elsewhere have chased the elusive Higgs boson for more than two decades. The University produced many of the leaders in theory and experimentation whose ideas and instruments have shaped the long quest for the crucial particle, at the LHC and at Fermilab near Chicago. Without the Higgs, theorists believe, the universe would contain no atoms, no elements, no stars, and no people.

The Higgs particle is named for Scottish physicist Peter Higgs, who sought to explain why some particles have mass and others don't. Bagging the Higgs boson was the first big prize on the LHC research agenda. If the Higgs boson is indeed what LHC physicists have found, the discovery has, like "42," its own ambiguous aspects.

"This is the beginning. We still don't know what this thing is," says Henry Frisch, professor in physics and a longtime member of the Collider Detector at Fermilab collaboration.

Finding a "missing piece" of modern theory

The new particle could be, as expected, the last missing piece of the Standard Model of particle physics, which describes the fundamental structure and behavior of ordinary matter. Or the particle could be something more exotic, such as a supersymmetric Higgs, offering insights into the mysteries of dark matter and dark energy, which together are thought to comprise 96 percent of the universe.

LHC physicists have searched for supersymmetry via multiple avenues, says James Pilcher, professor in physics. "So far all of these searches are coming up empty," Pilcher says. "Maybe we haven't been looking in the correct way so far. Maybe supersymmetry is hiding in some obscure corner that we haven't been able to explore yet."

Pilcher is one of six UChicago faculty members who belong to the ATLAS (A Toroidal LHC ApparatuS) collaboration at the LHC. Another is Melvyn Shochet, the Elaine M. and Samuel D. Kersten Jr. Distinguished Service Professor in Physics. Shochet agrees with Pilcher that discovering supersymmetric particles may take more time.

"String theory requires that there be supersymmetric partners of the particles that we know, but it doesn't require that they be in the mass range that has been studied so far," Shochet says. "It's very early in the game, and there's an awful lot to do."

Another LHC leader with UChicago roots is alumnus Joseph Incandela, BS'81, MS'85, PhD'96, a professor of physics at the University of California, Santa Barbara, and scientific spokesman for the European facility's other massive Higgs collaboration, called CMS (Compact Muon Solenoid).

UChicago ATLAS collaborator Frank Merritt, professor in physics, notes that over the last several decades, much of the progress made in particle physics has involved confirming details of the Standard Model, but a new era may be beginning.

"We're getting to a point now where we're certainly going to go beyond the Standard Model," Merritt says. "We don't know what we're going to see. It might be supersymmetry, it might be something else, but it's going to be a very exciting exploration."

Particles on the grid

A key element of this exploration will be the grid computing methods developed at UChicago and Argonne National Laboratory, which already have played a critical role in the Higgs search.

The fictional Deep Thought computer in Hitchhiker's Guide crunched numbers for millions of years before arriving at the cryptic answer "42." It took scientists far less time to pinpoint the mass of their newly discovered particle from data collected since 2011, thanks to the grid computing methods used for analyzing their latest results.

Computation Institute director Ian Foster helped invent grid computing, which allows people to share computer power, databases, and other online tools autonomously and securely across organizational and geographic boundaries.

"Building directly on concepts, methods, and software developed at Argonne and UChicago -- and, certainly, elsewhere -- the LHC Computing Grid distributes petabytes of data worldwide to hundreds of sites for reconstruction and analysis," observes Foster, the Arthur Holly Compton Distinguished Service Professor in Computer Science. "Without the LHC Computing Grid, the discovery could not have occurred."

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Understanding Heartburn: Day 5 ? Dr Nipun Aggarwal,MD, MBA, MHT

Gastroesophageal reflux disease, Esophagus, Heartburn, Gastric acid, Barrett's esophagus, Esophageal cancer, Esophagitis, Barrett

In Healthcare, Health, Medicine on September 3, 2012 at 8:00 am

What are the long-term complications of GERD?
Chronic GERD that is untreated can cause serious complications. Inflammation of the esophagus from refluxed stomach acid can damage the lining and cause bleeding or ulcers?also called esophagitis. Scars from tissue damage can lead to strictures? narrowing of the esophagus?that make swallowing difficult. Some people develop Barrett?s esophagus, in which cells in the esophageal lining take on an abnormal shape and color. Over time, the cells can lead to esophageal cancer, which is often fatal. Persons with GERD and its compli?cations should be monitored closely by a physician.
Studies have shown that GERD may worsen or contribute to asthma, chronic cough, and pulmonary fibrosis.

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Source: http://draggarwal.org/2012/09/03/understanding-heartburn-day-5/

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Ways to lose weight fast

Looking for a way to lose weight quickly? Then be prepared for a strict exercise and diet regime! Here?s the truth: most diets don?t really work and exercising alone is usually not enough to lose weight.

How weight loss works

Put simply, if you want to lose weight, you have to use more energy than you get from food. Recent technological advances have made our lives a lot more comfortable, which is making us spend increasingly more hours in front of TV screens or a computer monitors. That is one of the main reasons why obesity rates have skyrocketed in the Western countries.

Most diets don?t work

Most popular diets can?t provide long-term results. Here?s why:

• They place no emphasis on long term eating habits, instead focusing on a strict diet regime for a few weeks or months.
• Most weight loss diets cut out entire food groups, making it incredibly difficult for your body to tolerate the changes. Once the diet is over, most people fall back to their old eating habits.
• Some of these diets appear to work fast because they deprive you of liquids. Your body loses water mass (which is mostly stored in your muscles) quickly, but these results don?t last.
• By severely limiting food intake, some popular diets can leave you deprived of essential nutrients and minerals, causing various health conditions to develop.

What are the quickest ways to lose weight?

You can lose weight fairly quickly using an intensive exercise routine combined with a healthy eating plan. That?s about it.

The key thing here is this: if you want to successfully lose weight and keep it off, you must find a way to transform your current lifestyle into a much healthier one. That means getting plenty of regular exercise and eating healthy foods at all times.

Now, eating healthy doesn?t mean the same thing as going on a diet. Healthy eating plans encourage people to create good long-term eating habits by slowly changing their daily diets. This is crucial if you want to stay at a healthy weight for a long time. Here are a few tips to help you on your journey:

• Don?t force strict dietary changes on yourself. Make slow changes in order to avoid emotional resistance, which normally leads to relapse.
• Keep a detailed log of everything you eat. You will be surprised how many calories you actually consume in a normal day.
• Try to cook at home as often as possible. This way you?ll be able to choose what ingredients go into your meals.

There?s a lot more to successful weight loss than this, but these basics should have you well on your way. If you?d like to learn more about diets and various weight loss products, check out SlimmingToday.

Source: http://www.sweblogs.com/ways-to-lose-weight-fast/

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